Chemosensory Perception in Insects
Olfaction offers a wealth of biological problems awaiting understanding in molecular terms. We’re interested in the remarkable sensitivity of the olfactory system, its ability to distinguish among odors, and the mechanisms by which sensory input is translated into behavioral output. Drosophila has a highly sophisticated olfactory system, which we study with molecular, genetic, physiological, computational, and behavioral approaches.
Drosophila is able to taste a remarkable diversity of organic molecules. We discovered a family of 60 seven-transmembrane-domain genes, the Gr (Gustatory receptor) genes, and showed that they encode taste receptors. We are now integrating a study of taste receptors and an analysis of taste neurons to explore the molecular and cellular basis of taste. The goal is to define the functional organization of the taste system and the logic by which it encodes chemical information.
We are carrying out a functional analysis of the odorant receptors of the mosquito Anopheles gambiae, which transmits malaria. Female Anopheles detects and locates humans largely through olfactory cues. The work may lead to new means of controlling the transmission of malaria.
Su, C.-Y., Menuz, K., and J. Carlson (2009) Olfactory perception: receptors, cells, and circuits. Cell 139, 45-59.
van der Goes van Naters W. and Carlson J.R. (2006) Insects as chemosensors of humans and crops. Nature 444: 302-7.
Selected Research Articles:
Su, C.-Y., Menuz, K., Reiser, J. and Carlson J. (2012). Non-synaptic inhibition between grouped neurons in an olfactory circuit, Nature 492, 66-71.
Carey, A., Wang, G., Su, C.-Y., Zwiebel, L., and J. Carlson (2010). Odor reception in the malaria mosquito Anopheles gambiae Nature 464, 66-71.
Kreher, S., Mathew, D., Kim, J., and Carlson, J. (2008) Translation of sensory input into behavioral output via an olfactory system. Neuron 59, 110-124.
Ray, A., Van der Goes van Naters, W., and Carlson, J. (2008) A regulatory code for neuron-specific odor receptor expression. PLOS Biology 6, 1069-1083.
Dahanukar, A., Lei, Y., Kwon, J, and Carlson, J. (2007) Two Gr genes underlie sugar reception in Drosophila. Neuron 56, 503-516.
Ray A., van der Goes van Naters W., Shiraiwa T., and Carlson J.R. (2007) Mechanisms of odor receptor gene choice in Drosophila. Neuron 53, 353-69.
Hallem, E., and Carlson, J.R. (2006) Odor coding by a receptor repertoire. Cell 125, 143-160.
Kreher, S.A., Kwon, J.Y., and Carlson, J.R. (2005) The molecular basis of odor coding in the Drosophila larva. Neuron 46, 445-456.
Goldman A.L., Van der Goes van Naters W, Lessing D, Warr C.G., and Carlson J.R. (2005) Coexpression of two functional odor receptors in one neuron. Neuron 45, 661-666.
Hallem, E.A., Ho, M.G., and Carlson, J. (2004) The Molecular Basis of Odor Coding in the Drosophila Antenna, Cell 117, 965-979.
Hallem, E.A., Fox, N., Zwiebel, L., and Carlson, J.R. (2004) Olfaction: Mosquito Receptor for Human-Sweat Odorant, Nature 427, 212-213.
Dobritsa, A., van der Goes van Naters, W., Warr, C., Steinbrecht, A., and Carlson, J. (2003) Integrating the molecular and cellular basis of odor coding in the Drosophila antenna, Neuron 37, 827-841.
Dahanukar, A., Foster, K., van der Goes van Naters, W., and Carlson, J. (2001) A Gr Receptor is Required for Response to the Sugar Trehalose in Taste Neurons of Drosophila, Nature Neurosci. 12, 1182-1186.
de Bruyne, M., Foster, K., and Carlson, J. (2001) Odor coding in the Drosophila antenna, Neuron 30, 537-552.
Clyne, P., Warr, C. and Carlson, J. (2000) Candidate Taste Receptors in Drosophila, Science 287, 1830-1834.
Clyne, P., Warr, C., Freeman, M., Lessing, D., Kim, J., and Carlson, J. (1999) A Novel Family of Seven Transmembrane Proteins: Candidate Odorant Receptors in Drosophila, Neuron 22, 327-338.
Clyne, P., Certel, S., de Bruyne, M., Zaslavsky, L., Johnson, W., and Carlson, J. (1999) The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU Domain Transcription Factor, Neuron 22, 339-347.